Curriculum DAVID MARCILLA PLAZA

CURRENT TITLE AND POSITIONS: 

• 2002-2006: Internal resident Doctor (Anatomic Pathology): Virgen del Rocío University Hospital (Seville).
• July-September 2006: F.E.A Anatomic Pathology Juan Ramón Jiménez Hospital
• September 2006- January 2009: F.E.A Anatomic Pathology Riotinto Hospital
• Since 2009: F.E.A Anatomic Pathology UGC Virgen del Rocío- La Merced Hospital
• Member of the Muscular-Skeletal pathology committee since 2007.
• 2015: Pathologist Coordinator of the specialised areas of musculo-skeletal tissue and Uropatology of the Pathology Department. Hospital Viamed Santa Angela de la Cruz. Sevilla.
• 2015: Pathologist Coordinator of the specialised areas of musculo-skeletal tissue and Uropatology of the Seviston pathology laboratory. Seville.

• Master's Degree in Clinical Trials
• University: Seville Date of issue: 14 May 2012
• Advanced Studies Diploma (DEA). Cádiz University.

Scientific Activity:

1. Birth and evolution of the desmoplastic small round-cell tumour. Seminars in diagnostic Pathology. Elsevier.
2. Diagnostic difficulties of the hemophagocytic lymphohistiocytosis (HLH) associated with the Epstein-Barr virus. Journal of paediatric hematology and oncology.
3. Gastrointestinal stromal tumours (GISTs): SEAP-SEOM consensus on pathologic and molecular diagnosis. Clin Trasl Oncol.
4. Heterotopic parathyroid gland tissue in the parotid gland adjacent to a pleomorphic adenoma. Journal Craniomaxillofacial surgery.
5. Lower Extremity Fibro-Adipose Vascular Anomaly (FAVA): A New Case of a Newly Delineated Disorder. Annals of vascular disease.
6. Multidrug resistance transporter profile reveals MDR3 as a marker for stratification of blastemal Wilms tumour patients. Oncotarget.
7. Proteomic Profiling of Ewing Sarcoma Reveals a Role for TRAF6 in Proliferation and Ribonucleoproteins/RNA Processing. Journal of proteomics and bioinformatics.
8. Study and standardisation protocol of the pathological report of malignant soft tissue tumours and of intermediate behaviour of adolescents and adults. Spanish Journal of Pathology.
9. Sample study and standardisation protocol of the pathological report of bone tumours. Spanish Journal of Pathology.
10. Gastrointestinal stromal tumours: brief update and consensus of the SEAP-SEOM on pathological and molecular diagnosis. Spanish Journal of Pathology.
11. Langerhans cell Histiocytosis of algae evolution Bronchopneumology Archives. 2004 Sep; 40 (9):426
12. Renal oncocytomatosis in a patient receiving haemodialysis. Spanish Urology Archives. 2007 Sep; 60 (7):802-6.
13. Metastasis Crohn disease involving the penile foreskin. Spanish Urology Archives. 2006 Nov; 59 (9):902-5
14. Renal oncocytoma. Review of our series of 22 patients. Spanish Urology Archives. 2006 Jun; 30 (6):583-90
15. (99m) Tc-HDP SPECT/MRI in isolated xanthoma of the temporal bone. Rev Esp Med Nucl Imagen Mol. 2015 Sep-Oct; 34(5):329-30.
16. Sarcoidosis: simulating until the end. Journal of Respiratory Pathology. 2016; 19(1): 29-31
17. Expression of dog 1 in low -grade fibromyxoid sarcoma: A study of 19 cases and review of the literature. Annals of Diagnostic Pathology 30 (2017) 8-11

Collaboration in Research Projects:

1. Detection of pathognomonic gene fusions in sarcomas by mass sequencing to improve the diagnosis, stratification and treatment of patients. (Junta de Andalucía). 22/12/2016-21/12/2019.
2. Search, validation and clinical translation of new therapeutic targets from studies of genomics and integrative epigenomics in Ewing sarcomade. (Spanish Association Against Cancer)). 01/10/2013-30/08/2018.
3. EuroSarc- European clinical trials in rare Sarcomas within an integrated translational trial network. (Comisión Europea). 01/04/2015-31/05/2018.
4. New therapeutic targets in Ewing's sarcoma: study of the microenvironment. (Carlos III Health Institute). 01/01/2015-31/12/2017.
5. Relevance of Endoglin in the pathology of Ewing Sarcoma: Development of innovative personalised treatments. (Ministry of Finance and Civil Service). 01/01/2014-31/12/2017.
6. Study of the pathway suppressor of Hippo tumours in sarcoma and Ewing. Translational application for patient stratification and as a new therapeutic approach. (ANDALUSIAN PUBLIC PROGRESS AND HEALTH FOUNDATION). 01/08/2015-01/08/2017.
7. Registry of rare sarcomas: tools to help assess the number of cases of each subtype and their therapeutic orientation by the Spanish Research Group in Sarcomas (GEIS). 29/11/2013-31/03/2017